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Record W4415880996 · doi:10.1101/2025.11.02.686072

Century-old ethanol-preserved Vega Collection reveal the unexpected phylogeography of Slender bitterling <i>Tanakia lanceolata</i> in Japan

2025· preprint· W4415880996 on OpenAlexaff
Keisuke Tsuchiyama, Seigo Kawase, Yuko Takigawa, Tomohiko Fujita, Kazumi Hosoya, Jyun-ichi Kitamura, Tappei Mishina

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Language
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic diversity and population structure
Canadian institutionsMinistry of Environment
Fundersnot available
KeywordsBiological dispersalPhylogeographyGenetic diversityPopulationMitochondrial DNAPopulation genetics

Abstract

fetched live from OpenAlex

Abstract Recent genetic advancements offer new opportunities for studying natural history museum collections. The genetic analysis of century-old aquatic animal specimens, mostly preserved in ethanol, can provide valuable insights into the changes in genetic diversity caused by anthropogenic impacts. However, knowledge of the characteristics of degraded DNA from such specimens remains limited. In this study, we evaluated the DNA quality of bitterling fish, Tanakia lanceolata (Temminck and Schlegel), collected during the Vega Expedition in Japan in 1879 and preserved in ethanol. We then performed genomic analysis to test its hypothesized translocation-involved population history. The historical DNA was degraded, peaking around 50 bp, but a minor fraction exceeded 300 bp. Mitochondrial genetic analysis revealed high genetic similarity between the eastern and western sides of the Central Highland, typically impeding the dispersal of primary freshwater fish. These findings suggest an unexpected dispersal ability in T. lanceolata or undocumented translocations before the large-scale domestic translocations recorded since the 1910s. The customized workflow for historical ethanol-preserved specimens, based on historical DNA quality in this study, provides a foundation for studying historical archives.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.014
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.212
Teacher spread0.201 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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