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Record W4415885956 · doi:10.52573/ipmj.2025.148842

Diagnostic and Predictive value of Serum Anti C1q Antibody in a sample of Patients with Systemic Lupus Erythematous

2025· article· en· W4415885956 on OpenAlexaff
Israa Sukker, Faiq I. Gorial, Aida R. Al-Derzi

Bibliographic record

VenueIraqi postgraduate medical journal · 2025
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsInstitute of Infection and Immunity
Fundersnot available
KeywordsAntibodyRheumatologySystemic lupusSystemic lupus erythematosusDiseasePredictive valueComplement C1q

Abstract

fetched live from OpenAlex

Background: Anti C1q antibody is the most studied between antibodies directed against a component of the complement system. AntiC1q antibodies are present in patients with lupus, who often have high clinical disease activity. The aim is to assess Diagnostic and predictive value of serum anti C1q antibody in patients with SLE, to evaluate the correlation between serum anti C1q antibody with sociodemographic and clinical characteristic of SLE patients.Materials and methods: A total of 35 SLE patients and 35 apparently healthy individuals were selected as control group in the current study. Serum level of anti C1q antibody was detected by ELISA technique. This case control study was conducted at the Rheumatology Consultation Clinic of Baghdad Teaching Hospital, kidney Diseases and Transplant Center/ Medical City from January 2020 to September 2020.Results: There was a significant association between Anti C1q antibody and Systemic Lupus Erythematous Disease Activity Index Score. There was no significant association between Anti C1q antibody among patients or controls. There was no significant association between sociodemographic characteristics and anti C1q antibody. For laboratory investigations, there was no significant association with anti C1q antibody. There was no significant association between organ involvement and anti C1q antibody.Conclusion: As associated with SLE disease activity score suggesting its potential usefulness in assessment of disease activity, but not as accurate diagnostic marker, which is still need further elucidation and interpretation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.291
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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Same venueIraqi postgraduate medical journalSame topicSystemic Lupus Erythematosus ResearchFrench-language works237,207