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Record W4415900084 · doi:10.1016/s2352-3026(25)00256-x

Patient-reported outcomes with belantamab mafodotin, pomalidomide, and dexamethasone versus bortezomib, pomalidomide, and dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-8): a phase 3, open-label, randomised controlled trial

2025· article· en· W4415900084 on OpenAlexaff
Meletios Α. Dimopoulos, Meral Beksaç, Luděk Pour, Sosana Delimpasi, Vladimir Vorobyev, Hang Quach, Ivan Špıčka, Jakub Radocha, Paweł Robak, Kihyun Kım, Michèle Cavo, Kazuhito Suzuki, Jodie Wilkes, Simon McNamara, Amy Phillips-Jones, Kristin Morris, Farrah Pompilus, Molly Purser, Neal Sule, Brandon E. Kremer, Angély Loubert, Laurine Bunod, Manal M’Hari, Xiaoou L Zhou, Giulia Fulci, María-Victoria Mateos, Suzanne Trudel, Aaron Ronson, Adrián Alegre Amor, Alberto E. Velasco Valdazo, Amos Cohen, Andrew Lim, Antonia Sampol Mayol, Aristeidis Chaidos, Artur Jurczyszyn, Aurore Perrot, Bradley Augustson, Britta Besemer, Cecily Forsyth, Celia Suriu, Chang‐Ki Min, Cindy Lee, Clifton C. Mo, Dmitriy Kirtbaya, Edwin Lee, Eleftheria Hatzimichael, Eda Nur Kozan, Esther González García, Estrella Carrillo Cruz, Güldane Cengiz Seval, Güner Hayri Özsan, Güray Saydam, Hanlon Sia, Hannah Hunter, Hiroshi Handa, Hyeon‐Seok Eom, Ian Irving, И. Л. Давыдкин, Inna Tsoran-Rosenthal, Irit Avivi, Iurii Osipov, Ja Min Byun, Jae Hoon Lee, Jarosław Czyż, Javier de la Rubia Comos, Je Jung Lee, Jean‐Marc Schiano de Colella, Jesús G. Berdeja, Jin Seok Kim, Jock Simpson, Johnny Francisco Cordeiro Camargo, Kaichi Nishiwaki, Kamaraj Karunanithi, Kathryn Forwood, Kazutaka Sunami, Keith Fay, Kevin Boyd, Koji Kawamura, Konstantinos Anargyrou, Kosei Matsue, Laura Fogliatto, Laura Rosiñol Dachs, Magdalena Dutka, Manuel Modiano, Marcelo Pitombeira de Lacerda, Maria Del Carmen Martinez Chamorro, Marie Hughes, Markus Munder, Martin Kortuem, Matteo Da Vià, Matthew Jenner, Maurizio Martelli, Mehmet Sinan Dal, Mehmet Turgut, Melita Kenealy, Merit Hanna, Michail Iskas, Nicole Chien, Olga Uspenskaya, Osnat Jarchowsky, Paula Rodríguez‐Otero, Pierre Feugier, Sergey Voloshin, С. В. Семочкин, Sharon Jackson, Shigeki Ito, Shinsuke Iida, Silvia Mangiacavalli, Suman Kambhampati, Tadeusz Robak, Takayuki Ikezoe, Tomasz Wróbel, Vânia Hungria, Vera Zherebtsova, Vidya Mathavan, Wei Yang, Xin Du, Zafer Gülbaş, Zübeyde Nur Özkurt

Bibliographic record

VenueThe Lancet Haematology · 2025
Typearticle
Languageen
FieldMedicine
TopicMultiple Myeloma Research and Treatments
Canadian institutionsPrincess Margaret Cancer Centre
FundersGlaxoSmithKline
KeywordsDexamethasoneMultiple myelomaRefractory (planetary science)Randomized controlled trialPhases of clinical research

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.355
Teacher spread0.307 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractno

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