MétaCan
Menu
Back to cohort

97 Statistical and systematic uncertainties affect biomarker reliability: a case study in multiplex immunofluorescence

2025· article· W4415900298 on OpenAlexaff
Jeffrey S Roskes, Benjamin Green, Emily B. Cohen, Margaret Eminizer, Sam J Tabrisky, Sigfredo Soto-Diaz, Boyang Zhang, Daphne Wang, Daniel Jiménez‐Sánchez, Justina X. Caushi, Jiajia Zhang, Nina M. D’Amiano, Joel Sunshine, J.S. Deutsch, Sonali Uttam, Alexa Fiorante, Nicole Espinosa, Teodora Popa, Aleksandra Ogurtsova, Andrew Jorquera, Jamie E. Chaft, Julie R. Brahmer, Michael Conroy, Joshua E. Reuss, Hongkai Ji, Patrick M. Forde, Drew M. Pardoll, Kellie N. Smith, Alexander S. Szalay, Janis M. Taube, Tricia R. Cottrell

Bibliographic record

VenueRegular and Young Investigator Award Abstracts · 2025
Typearticle
Language
FieldDecision Sciences
TopicReliability and Agreement in Measurement
Canadian institutionsQueen's University
Fundersnot available
KeywordsMultiplexBiomarkerImmunofluorescenceAffect (linguistics)

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.020
metaresearch head score (Gemma)0.028
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Scholarly communication
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.088
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0200.028
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.069
GPT teacher head0.344
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractno

Explore more

Same venueRegular and Young Investigator Award AbstractsSame topicReliability and Agreement in MeasurementFrench-language works237,207