Storage Stability of Hb A1c in Whole Blood Samples
Bibliographic record
Abstract
Blood glycated hemoglobin (Hb A1c) is a recommended biomarker for diagnosing and monitoring diabetes. Ensuring the stability of Hb A1c in stored blood is essential for accurate measurement. Although it has been shown that Hb A1c remains stable for at least 1 year at −80°C to −70°C (1), 2 weeks at 4°C (2), 1 month at −20°C (3), and 3 days at room temperature (15°C to 30°C) (4), the stability of Hb A1c during onboard storage on the analyzer has not been studied. In addition, the cumulative processing time of samples on the analyzer can result in delays. Hospital laboratories also frequently receive requests for additional testing on the same day for previously collected specimens. To accommodate these requests, laboratories routinely store specimens for a defined period (1 to 4 h) at RT after the initial testing before long-term storage. This practice ensures sample availability for add-on tests and prevents additional phlebotomy. Storing samples on an instrument system at RT and reusing them for add-on tests may present stability concerns and a risk of carryover. Therefore, this study investigates Hb A1c stability in whole blood stored on the analyzer and the potential carryover into adjacent blood and serum specimens.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".