Real-World Effectiveness of Upadacitinib in Moderate-to-Severe Atopic Dermatitis: Results from Longitudinal Analyses in 6- and 12-month Cohorts From the PPD CorEvitas Atopic Dermatitis Registry
Bibliographic record
Abstract
Introduction: Clinical trials previously established the short and long-term efficacy and safety of upadacitinib (UPA) for the treatment of atopic dermatitis (AD). Here we report 12-month real-world effectiveness of UPA in adults from the PPD™ CorEvitas™ AD Registry. Materials and Methods The PPD™ CorEvitas™ AD Registry is a prospective, non-interventional registry of adults with AD in the US and Canada. Participants in this analysis were enrolled through May 30, 2025, with data available for the baseline and 12-month follow up visit, at which they were receiving UPA treatment. We report on achievement of validated Investigators Global Assessment Scale for AD of “clear” or “almost clear” (vIGA-AD 0/1) for participants with a score ≥2 at baseline, improvement of ≥90%/100% from baseline in Eczema Area and Severity (EASI 90/100), Peak Pruritus Numeric Rating Scale PP-NRS score of 0 or 1 for participants with a baseline score ≥1 (PP-NRS 0/1; little-to-no itch), Dermatology Life Quality Index score of 0 or 1 for participants with a baseline score ≥1 (DLQI 0/1; no effect on quality of life [QoL]), and simultaneous achievement of EASI 90 + PP-NRS 0/1. Proportions are reported as observed with no imputation. Safety was not assessed in this analysis. Results A total of 189 participants were included in the 12-month analysis (mean age at baseline 47.2 years, 53.4% female, and 39.7% had prior biologic experience). Most participants (65.5%, 114/174) achieved vIGA-AD 0/1, and EASI 90 (62.2%; 112/180); nearly half (48.9%; 88/180) achieved EASI 100. Many participants reported little-to-no itch (41.4%; 70/169) and no effect of AD on QoL (44.6%; 78/175). Over one-third (37.9%; 61/161) of participants achieved simultaneous EASI 90 + PP-NRS 0/1. These results are comparable with the results of a separate 6-month visit cohort analysis. Conclusion In a real-world setting, many patients with 12 months of treatment with upadacitinib reported little-to-no itch, clear or almost clear skin, including simultaneous achievement of skin clearance and itch relief, and no impact of AD on their QoL. The comparable achievement of optimal treatment targets at 6- and 12-months underscore UPA long-term consistency and effectiveness in AD treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.015 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".