Most Baricitinib Responders Achieved Full Scalp Hair Regrowth: Findings from Adult and Paediatric BRAVE-AA Trials
Bibliographic record
Abstract
Background Achievement of full scalp hair regrowth is an important outcome for patients with severe AA. Baricitinib is a selective JAK inhibitor that is approved in adults to treat severe AA and has now been studied in 257 adolescents (ages 12 to <18 years). In both populations, significant scalp hair regrowth (SALT score <20) was achieved in clinical trials. This analysis evaluates complete response thresholds of SALT score <10 and <5 among SALT score <20 responders, through Weeks (Wk) 36 and 52 in adolescent and adult populations, respectively. Methods Among BRAVE-AA1/2 (NCT03570749, NCT03899259) and BRAVE-AA-PEDS (NCT05723198) trials, baricitinib 4mg and 2mg responders (SALT score ≤20) were evaluated for achievement of SALT score ≤10 or ≤5 at Wk4, 8, 12, 16, 24, 36, and 52*. Results Among those patients treated with baricitinib 4mg, the proportion of adult responders who achieved SALT score <10 at Wk36 and Wk52 was 74.6% (150/201) and 75.0% (171/228); and the proportion in adolescents at Wk36 was 86.1% (31/36). Among those patients treated with baricitinib 4mg, the proportion of adults who achieved SALT score <5 at Wk36 and Wk52 was 55.2% (111/201) and 62.7% (143/228); and the proportion in adolescents at Wk36 was 61.1% (22/36). Some patients achieved these responses as early as Wk8 in both adult and adolescent populations.Among those patients treated with baricitinib 2mg, the proportion of adults who achieved SALT score <10 at W36 and W52 was 62.2% (51/82) and 71.0% (66/93); and the proportion in adolescents at W36 was 78.3% (18/23). Among those patients treated with baricitinib 2mg, the proportion of adults who achieved a SALT score <5 at W36 and W52 was 42.7% (35/82) and 47.3% (44/93); and the proportion in adolescents at W36 was 60.9% (14/23). Some patients achieved these responses as early as W8 in both adult and adolescent populations. Conclusion Baricitinib treated adult and adolescent patients who were responders (SALT score ≤20) had increasing depth of response over time with continued therapy, and the majority achieved full scalp hair regrowth. Footnote *Week 52 data is not yet available for the BRAVE-AA-PEDS trial.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".