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Medicinal Plant-Based Immunostimulants for Sustainable Shrimp Farming: From Bioactive Compounds to Reproductive Enhancement

2025· article· en· W4416318844 on OpenAlex
Nader N. Hassona, Ahmed A. Elshafey, Yun Li, Xilin Dai

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueEgyptian Journal of Veterinary Science · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicInvertebrate Immune Response Mechanisms
Canadian institutionsMinistry of Agriculture
Fundersnot available
KeywordsShrimpHormoneEyestalkEndocrine systemFishingMedicinal plants

Abstract

fetched live from OpenAlex

The expansion of intensive shrimp aquaculture, driven by global food demand, is challenged by disease outbreaks and reliance on unsustainable practices like eyestalk ablation to induce reproduction in broodstock. This review explores the potential of medicinal plant-based immunostimulants as a sustainable alternative, with a specific focus on enhancing the reproductive performance of the Pacific white shrimp, Penaeus vannamei. We detail the complex endocrine regulation of crustacean reproduction, highlighting the roles of the X-organ-sinus gland complex, mandibular organ, and key hormones like methyl farnesoate. This foundation underscores the mechanistic drawbacks of eyestalk ablation, creating a compelling need for natural interventions. The paper then synthesizes evidence on how bioactive phytochemicals, including flavonoids, alkaloids, and sterols, can stimulate growth, immunity, and gonadal maturation. A thorough analysis of two promising plants, Melastoma malabathricum (Karamunting) and Cyperus spp., is presented. M. malabathricum, rich in lanosterol, acts as a precursor for steroid hormones, significantly accelerating ovarian development, increasing oocyte size, and elevating progesterone levels in P. vannamei. Conversely, Cyperus spp. contains methyl farnesoate, a crustacean juvenoid hormone analog, which promotes vitellogenesis, spermatogenesis, and molting, leading to advanced gonadal maturation stages and improved spawning performance. By compiling the molecular and endocrine evidence, this review positions these herbal extracts as effective, natural, and welfare-friendly alternatives to synthetic hormones and invasive techniques, offering a viable strategy to enhance reproductive efficiency and sustainability in shrimp hatcheries.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.038
Threshold uncertainty score0.816

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.306
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it