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Record W4416388687 · doi:10.1038/s43246-025-00978-x

Evaluation of radiochromic formulations for dosimetry in high-energy photon and proton beams

2025· article· en· W4416388687 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueCommunications Materials · 2025
Typearticle
Languageen
FieldMedicine
TopicRadiation Therapy and Dosimetry
Canadian institutionsUniversity of TorontoUniversity Health NetworkLaurentian UniversityTRIUMFOkanagan University CollegePrincess Margaret Cancer CentreKelowna General HospitalUniversity of VictoriaYork University
FundersNatural Sciences and Engineering Research Council of CanadaCanada First Research Excellence FundCanadian Institutes of Health ResearchTRIUMFMitacsUniversity of TorontoCanada Foundation for Innovation
KeywordsDosimetryDosimeterIonizing radiationRadiationProtonPhotonIrradiationRange (aeronautics)

Abstract

fetched live from OpenAlex

Radiochromic crystals have many suitable features for dosimetry across a broad range of radiotherapy modalities, yet the study of these materials within the medical physics community has been limited. Here, we study three types of radiochromic pentacosa-10,12-diynoic acid-based formulations: two analogues of commercially available materials and one newly developed. Formulations coated on polyethylene are irradiated with photon (6 and 10 MV) and proton (74 MeV) beams (0–25 Gy) using custom fibre-optic setups that enable real-time transmission measurements at 1.5–2 cm depth to maintain dosimetric accuracy. The dose response to ionizing radiation is compared between the formulations and all formulations were characterized using a variety of analytical methods. The response of radiochromic crystals to ionizing radiation is complex and influenced by factors such as monomer composition and resulting macroscopic crystal morphology. By optimizing these parameters, it could be possible to develop dosimeters suitable for a variety of clinical applications. Even though radiochromic crystals are promising for dosimetry in diverse radiotherapy modalities, and their response can be optimized through monomer composition, exploration of these materials in this context remains limited. Here, three pentacosa-12,12-diynoic acid-based formulations are studied

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.157
Threshold uncertainty score0.306

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.359
Teacher spread0.321 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it