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Record W4416391742 · doi:10.1016/j.annonc.2025.09.077

LBA65 Neoadjuvant durvalumab (D) + chemotherapy (CT) followed by either surgery (Sx) and adjuvant D or CRT and consolidation D in patients (pts) with resectable or borderline resectable stage IIB–IIIB NSCLC: Interim analysis (IA) of the phase II MDT-BRIDGE study

2025· article· en· W4416391742 on OpenAlexafffund
M. Reck, Nicolas Girard, Ernest Nadal, C.M. Gay, Andrea Riccardo Filippi, L.W. Martin, Cordula Petersen, David A. Cairns, Benoît Roch, Ilaria Attili, Rafael Álvarez, Alexandre Boyer, Margarita Majem, Arelis Robinson, E.L. Buchmeier, Matteo Giaj Levra, Li Li, I. Diaz Perez, N.E. Georgoulia, Jonathan Spicer

Bibliographic record

VenueAnnals of Oncology · 2025
Typearticle
Languageen
FieldMedicine
TopicCancer Immunotherapy and Biomarkers
Canadian institutionsMcGill UniversityAstraZeneca (Canada)Kingston General Hospital
FundersJiangsu Cancer HospitalCancer Institute and Hospital, Chinese Academy of Medical SciencesUniversity of Chicago MedicineBetta PharmaceuticalsState Key Laboratory of Molecular OncologyGuangxi Medical UniversityXiamen UniversitySchool of Medicine, Stanford UniversityTianjin Medical UniversityWeill Cornell Medical CollegePeking UniversityDirectorate for Biological SciencesUniversidad de Las Palmas de Gran CanariaUniversité de MontréalUniversity of Chinese Academy of SciencesZhejiang UniversityChinese Academy of Medical SciencesTongji UniversityPeking Union Medical CollegeHuazhong University of Science and TechnologyDalian University of TechnologyShandong UniversitySichuan UniversitySun Yat-sen UniversityMcGill UniversityMcGill University Health CentreChinese Academy of SciencesWest China Hospital, Sichuan UniversityLanzhou UniversityStanford Cancer InstituteHarbin Medical UniversityMemorial Sloan-Kettering Cancer CenterDeutsches Zentrum für LungenforschungAstraZeneca
KeywordsDurvalumabInterimNeoadjuvant therapyChemotherapyAdjuvantStage (stratigraphy)

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.055
GPT teacher head0.404
Teacher spread0.350 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractno

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