Measurable residual mutated NPM1 before allogeneic transplant for acute myeloid leukemia
Bibliographic record
Abstract
NPM1 mutations ( NPM1 m), seen in ~30% of adults with acute myeloid leukemia (AML), often co-occur with FLT3 internal tandem duplication ( FLT3 -ITD) [ 1 , 2 ]. Measurable residual disease (MRD) testing in first complete remission (CR) identifies patients at high risk of relapse after allogeneic hematopoietic cell transplantation (alloHCT) [ 3 , 4 ]. Quantitative RT-PCR assays are currently recommended for NPM1 MRD testing, while FLT3 -ITD MRD testing is DNA-based using next generation sequencing (NGS) [ 5 , 6 , 7 ]. DNA-based NGS assays for NPM1 MRD testing may offer advantages over RNA, including improved template stability, accurate quantification, and high throughput capabilities, but require validation. We performed NPM1 MRD detection in blood collected from patients with AML during first CR (CR1) prior to alloHCT using a highly sensitive, commercially available DNA-based NPM1 NGS MRD assay.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".