Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice
Bibliographic record
Abstract
Adolescent stress can lead to persistent behavioral issues and brain dysfunction, often linked to sensory perception abnormalities. The biological basis for these sensory changes is not well understood. Here, we demonstrate that social isolation during adolescence, but not adulthood, remodels the structure and function of brain circuits that process touch in mice. Specifically, isolation increases the number of afferents to each neuron while weakening individual connections, and these changes depend on the activation of glucocorticoid receptors in thalamic neurons. Mice exposed to adolescent isolation also show reduced ability to distinguish fine tactile differences, suggesting a functional impact of the altered thalamic circuitry. Cohabitation with another mouse can partially reverse the synaptic effects of adolescent isolation. Our findings identify the sensory thalamus as a vulnerable site for adolescent stress and show how social experiences during this period can remodel sensory circuits, providing new directions for preventing or treating stress-related sensory problems.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".