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Record W4416668874 · doi:10.1007/s00431-025-06659-8

Beyond the seizure: the role of post-event observation in febrile seizure management

2025· article· en· W4416668874 on OpenAlexaff
Gidon Test, Ana Luiza Zigman, Dennis Scolnik, Vered Wiesel, Y. Hasan, Remah Yousef, Oren Tavor, Inbal Kestenbom, Or Kaplan

Bibliographic record

VenueEuropean Journal of Pediatrics · 2025
Typearticle
Languageen
FieldMedicine
TopicEpilepsy research and treatment
Canadian institutionsHospital for Sick Children
FundersBen-Gurion University of the Negev
KeywordsFebrile seizureEpilepsyFebrile convulsionsEl NiñoNeurological disorderCentral nervous system disease

Abstract

fetched live from OpenAlex

Simple febrile seizures (SFS) are a common cause of pediatric emergency department (PED) visits. Guidelines discourage extensive workup for children presenting with SFS, but there is little consensus on whether, or how long, to observe these patients. The objective of this study is to identify clinical, demographic, and historical factors associated with short-term seizure recurrence which might merit an observational period in children who have suffered a febrile seizure. This retrospective cohort study included children aged 12 months to 5 years who presented to the PED with a single generalized seizure in the setting of fever ≥ 38 °C. Current hospital policy recommends a 6-h period of observation in the PED for all such children, and admission for those who undergo a second seizure. Statistical analyses included comparisons between children with and without seizure recurrence, and logistic regression to identify predictors of hospitalization. Of 1496 children screened, 1404 met inclusion criteria. Seizure recurrence occurred in 27 (1.9%) of patients-all within 3 h of presentation. None of the following factors predicted seizure recurrence: gender, ethnic group, family history of febrile seizures, prior SFS, duration of fever before seizure, or peak fever. CONCLUSION: The short-term recurrence of febrile seizures was low (1.9%) and occurred within hours of the index seizure. Since the recurrence rate was low, and considering the benign outcomes of SFS, an observation period may not be warranted. Children who are stable and have regained neurological function may be considered for early discharge with appropriate caregiver education and follow-up, as already practiced in some centers. WHAT IS KNOWN: • Simple febrile seizures are frequent and often benign occurrences in children. • Guidelines discourage extensive tests but omit specific observation protocols. WHAT IS NEW: • Seizure recurrence after simple febrile seizures is very low and usually occurs within the first 3 h after the initial seizure. • After a simple febrile seizure, children may be considered for early discharge once they return to baseline function, without the need for an extended observation period.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.219
Threshold uncertainty score0.200

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.265
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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