A Comprehensive Literature Review Examining the Efficacy of Autologous Intra-Ovarian Platelet-Rich Plasma in Women Diagnosed with POI and DOR and its Impact on ART Outcomes
Bibliographic record
Abstract
Background: This extensive literature review examines the potency of autologous intra-ovarian platelet rich plasma (PRP) in women diagnosed with primary ovarian insufficiency (POR) and reduced ovarian reserve (DOR). Recent research has investigated PRP as a possible method to help improve ovarian function and improve fertility outcomes for these groups of patients. Methods: A systematic search of medical databases was done in PubMed, Cochrane Library, Embase, and Web of Scopus done to identify relevant studies published from 2014 up to 2024. Inclusion criteria included observation studies, cohort studies and randomized controlled trials. Data extraction focused on changes in ovarian reserve parameters and ART outcomes like pregnancy rates, live birth rates and embryo quality. The studies were assessed for quality using the Newcastle-Ottawa Scale for observational studies and cohort studies and the Cochrane Risk of Bias Tools to assess the bias risk in randomized controlled trials. Results: By using the MeSH terms related to “platelet-rich plasma,” “intra-ovarian injection” and “Diminished Ovarian Reserve", several additional relevant keywords were identified. This led to an initial search that produced 297 articles. After applying the criteria for inclusion and exclusion to evaluate these articles for eligibility,10 studies were selected for review which included a total of 1516 women. The papers included 2 randomized controlled trails, 1 retrospective study and 7 prospective studies. Discussion: Intraovarian PRP injections show potential in enhancing ovarian function and outcomes for women with POR and POI, with some studies reporting improvements in ovarian reserve markers and pregnancy rates. However, others indicate limited benefits, highlighting variability in methodologies and PRP preparation. Future research should standardize procedures and conduct larger trials to better understand PRP's mechanisms and its impact on long-term reproductive outcomes. Conclusion: Intra-ovarian PRP shows promise as a therapeutic option for women with POI and DOR, demonstrating improvements in ovarian reserve parameters and ART outcomes like the rates of clinical pregnancy and live births. However, further large-scale, randomized controlled trails are required to establish its extended duration of efficacy and safety. While encouraging, current evidence suggests that PRP should be considered an experimental treatment requiring additional research before widespread clinical application.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.025 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.005 |
| Bibliometrics | 0.014 | 0.013 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".