Impact of expanding allogeneic stem cell transplantation on survival in acute myeloid leukemia: a population-based study
Bibliographic record
Abstract
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age at diagnosis of 69 years and a five-year overall survival (OS) of only 23%—dropping to 10% in patients aged ≥65 [ 1 ]. For patients with an estimated relapse risk over 35–40%, consolidation with allogeneic stem cell transplant (alloHCT) is standard of care [ 2 ]. Although there is no upper limit of age cutoff, historically, older adults have often been excluded from alloHCT due to concerns regarding treatment-related toxicity (TRM) and non-relapse mortality (NRM). While multiple retrospective and matched analyses support improved progression-free survival and OS with alloHCT [ 3 , 4 , 5 , 6 ], other studies have raised concerns about its benefit in older patients, citing limited OS gains and negative impacts on quality of life [ 7 , 8 , 9 ].
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".