Relief of Refractory Angina With Vericiguat
Bibliographic record
Abstract
BACKGROUND: Refractory angina represents a challenging clinical symptom, with limited therapeutic options beyond conventional antianginal therapy and revascularization. CASE SUMMARY: A 43-year-old man with a history of hypertension, diabetes mellitus, and coronary atherosclerotic heart disease presented with persistent angina pectoris, classified as Canadian Cardiovascular Society class IV, despite being on optimized antianginal therapy including calcium-channel blockers, nitrates, and other adjunctive medications. His Seattle Angina Questionnaire score was 12.61. Introduction of vericiguat 10 mg daily resulted in marked symptom improvement, with Seattle Angina Questionnaire score increasing to 57.35 and angina classification improving to class II. DISCUSSION: This represents to our knowledge the first documented use of vericiguat for refractory angina. Vericiguat stimulates soluble guanylate cyclase and enhances cyclic GMP production, improving endothelial dysfunction and impaired vasodilation; this may be the mechanism by which it relieves refractory angina. TAKE-HOME MESSAGES: Vericiguat may offer therapeutic benefit in refractory angina patients unresponsive to conventional therapy. Further investigation is warranted.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".