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Record W4416754310 · doi:10.1101/2025.11.24.25340890

Post-pandemic Spread of Influenza and RSV in a Child Care Facility in Ontario in the Presence of Vaccination

2025· preprint· W4416754310 on OpenAlexafffundabout
Darren Flynn-Primrose, Bridgette Amoako, Lia Humphrey, Edward W. Thommes, Jason K. H. Lee, Dion Neame, M Cojocaru

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Language
FieldMathematics
TopicCOVID-19 epidemiological studies
Canadian institutionsUniversity of GuelphCanadian Institute for Health InformationUniversity of British ColumbiaMcGill University
FundersNatural Sciences and Engineering Research Council of CanadaSanofi
KeywordsVaccinationTransmission (telecommunications)Child careEpidemiologySeasonal influenzaHealth carePathogenChild health

Abstract

fetched live from OpenAlex

A bstract We present a mathematical model of a daycare center in Ontario to investigate concurrent pathogen transmissions among students (1.5 to 4 years) and teachers in a simulated child care center. The pathogens included are seasonal influenza and RSV. The model simulates detailed movements and interactions within a structured childcare environment, enabling analysis of pathogen exposure, infection rates, and transmission dynamics. Simulations incorporate empirical contact data collected from an Ontario daycare facility, existing values of epidemiological parameters, and publicly available health statistics. Pathogens are assumed to be introduced from outside of the facility, and the model provides estimates of infection rates within the childcare facility, as well as likelihood of re-introduction from offsite. Results derived from the model further explore the impact of existing and potential vaccination strategies on diseases transmission. We explore scenarios reflecting current vaccination uptake for influenza, as well as potential uptake and efficacy of a novel RSV vaccine.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.075
Threshold uncertainty score0.151

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.148
GPT teacher head0.392
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes3
Has abstractyes

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Same venuemedRxiv→Same topicCOVID-19 epidemiological studies→French-language works237,207→