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Record W4416786514 · doi:10.1371/journal.pntd.0013696

Benefit-cost analysis of raccoon rabies control in Ontario, Canada

2025· article· en· W4416786514 on OpenAlexaffabout
Stephanie A. Shwiff, Emily Sohanna Acheson, Levi Altringer, Patrick A. Leighton, Larissa Nituch, Sarah Sykora, François Viard, Tore Buchanan

Bibliographic record

VenuePLoS neglected tropical diseases · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicRabies epidemiology and control
Canadian institutionsCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-MontréalMinistry of Natural Resources and ForestryCegep de Saint HyacinthePublic Health Agency of Canada
Fundersnot available
KeywordsRabiesZoonosisPublic healthCase fatality rateVaccinationEpidemiologyOne HealthWildlife

Abstract

fetched live from OpenAlex

Zoonotic diseases, particularly those originating in wildlife, pose significant public health and economic risks. Rabies, a viral zoonosis with near-100% case fatality in humans, is a prime example of such a threat, especially in regions like North America where wildlife-such as raccoons-serve as key reservoirs. This study assesses the economic efficiency of Ontario, Canada's raccoon rabies control program, which combines oral rabies vaccination (ORV), trap-vaccinate-release (TVR), and surveillance strategies. Using a spatial agent-based epidemiological model, the study estimates the benefits and costs of intervention compared to a no-intervention scenario over the period 2015-2025. Benefits were quantified as avoided public health costs, including post-exposure prophylaxis (PEP), animal testing (AT), and human exposure investigations (INVT), and converted to 2023 CAD. Results show that the intervention prevented significant economic losses, with benefit-cost ratios ranging from 1.5 to 14.16 depending on assumed rates of intervention necessity, confirming the program's cost-effectiveness. This analysis not only supports continued investment in wildlife rabies control but also provides a scalable economic framework for other zoonotic disease management programs utilizing a One Health approach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.074
Threshold uncertainty score0.534

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.002
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.212
Teacher spread0.205 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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