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Record W4416821133 · doi:10.1038/s42003-025-09294-z

Light-harvesting by antenna-containing xanthorhodopsin from an Antarctic Pseudanabaenaceae cyanobacterium

2025· article· en· W4416821133 on OpenAlexfundno aff
Marı́a del Carmen Marı́n, Shunya Murakoshi, Andrey Rozenberg, Tatsuki Tanaka, Masae Konno, Wataru Shihoya, Osamu Nureki, Oded Béjà, Keiichi Inoue

Bibliographic record

VenueCommunications Biology · 2025
Typearticle
Languageen
FieldNeuroscience
TopicPhotoreceptor and optogenetics research
Canadian institutionsnot available
FundersAzrieli FoundationBrain Science Foundation
KeywordsCyanobacteriaHalophilePhototrophExtreme environmentBacteriaPhotosynthesisChromophore

Abstract

fetched live from OpenAlex

Microbial rhodopsins are light-sensitive proteins vital to various phototrophic and sensory processes in microorganisms. Xanthorhodopsins, with their dual chromophore system involving retinal and carotenoids, have been predominantly studied in the extreme halophilic bacterium Salinibacter ruber and in the early-branching thylakoid-less cyanobacterium Gloeobacter violaceus, where they facilitate light-driven outward proton pumping. However, their distribution, binding specificity, and ecological significance in cyanobacteria remain poorly understood. Here we report the incidence of xanthorhodopsin genes in cyanobacterial genomes and characterize psXR, a xanthorhodopsin from an uncultured Antarctic cyanobacterium from the filamentous family of Pseudanabaenaceae that binds a hydroxylated carotenoid antenna. Through bioinformatic, spectroscopic, functional and structural analyses, we determine the properties of psXR and potential physiological roles of cyanobacterial xanthorhodopsins. Our findings suggest xanthorhodopsins' role in modulating light-harvesting efficiency in cyanobacteria, particularly in extreme environments. The antenna binding and associated structural changes likely provide selective advantages for adapting to polar light conditions such as prolonged low light intensities and spectral shifts, contributing to cyanobacterial survival in harsh habitats.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.103
Threshold uncertainty score0.667

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.073
GPT teacher head0.389
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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