Association of Sarcopenia with Pain and Disability in Hand Osteoarthritis: A Retrospective, Cross-Sectional, Single-Center Study
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
BACKGROUND/AIMS: Sarcopenia is known to worsen clinical outcomes in osteoarthritis, particularly in weight-bearing joints, yet its relationship with symptom burden in hand osteoarthritis has not been well established. This study explored the relationship between sarcopenia, hand pain, and functional status in patients with hand osteoarthritis. MATERIALS AND METHODS: A retrospective analysis was conducted on 1139 patients aged ≥40 years with radiographically confirmed hand osteoarthritis. Sarcopenia was defined as the ratio of muscle mass to body mass index, measured via bioelectrical impedance analysis. Hand pain and function were assessed using the Australian/Canadian Osteoarthritis Hand Index, and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaires. Sex-specific multivariable linear regression models were constructed, adjusting for demographic and lifestyle covariates. RESULTS: In males, lower appendicular skeletal muscle mass/body mass index was significantly associated with higher DASH scores (estimate: -10.664, P = .006). A significant association with higher Australian/Canadian Osteoarthritis Hand Index scores was also observed (estimate: -26.236, P = .030). Lower upper-extremity muscle mass/body mass index was likewise associated with higher DASH scores in males (estimate: -41.074, P = .013). In females, none of the associations reached statistical significance. CONCLUSION: These findings suggest that sarcopenia contributes to increased pain and disability in hand osteoarthritis, highlighting the clinical importance of preserving muscle mass in its management. Cite this article as: Lee H, Lee S-I, Cheon Y-H, et al. Association of sarcopenia with pain and disability in hand osteoarthritis: a retrospective, cross-sectional, single-center study. Arch Rheumatol. 2025;40(4):492-498.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it