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Record W4416859651 · doi:10.1164/rccm.202509-2336st

Racial, Ethnic, Sex, and Gender Equity for Inclusive Interstitial Lung Disease Research: An Official American Thoracic Society Research Statement

2025· article· en· W4416859651 on OpenAlexfundno aff
Deborah Assayag, Ayodeji Adegunsoye, Yet H. Khor, Francesco Bonella, Raphaël Borie, Ivette Buendía-Roldán, Nazia Chaudhuri, Kevin F. Gibson, Kerri A. Johannson, Naftali Kaminski, John S. Kim, Sydney B. Montesi, Nadia Nathan, Anne‐Marie Russell, Claudia Valenzuela, Marlies Wijsenbeek, Vincent Cottin, Yolanda Mageto

Bibliographic record

VenueAmerican Journal of Respiratory and Critical Care Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Canadian institutionsnot available
FundersMedical Research CouncilGenentechNational Institutes of HealthEuropean Respiratory SocietyBristol-Myers SquibbFaculty of Health and Medical Sciences, University of Western AustraliaUnited Therapeutics CorporationGalectoThoracic Society of Australia and New ZealandGlaxoSmithKlineLung Foundation AustraliaShionogiRoyal Australasian College of PhysiciansSorbonne UniversitéLung Foundation NetherlandsInstitut National de la Santé et de la Recherche MédicaleSanofiAustin Medical Research FoundationMcGill UniversityNational Health and Medical Research CouncilAstraZenecaCSL BehringF. Hoffmann-La RocheFibroGenDaiichi-SankyoNational Heart, Lung, and Blood InstituteErasmus Universitair Medisch Centrum RotterdamSavara PharmaceuticalsAmgen
KeywordsInclusion (mineral)Interstitial lung diseaseClinical trialHealth equityEquity (law)Generalizability theoryMEDLINEMultidisciplinary approach

Abstract

fetched live from OpenAlex

Abstract Rationale Equitable care for all individuals living with interstitial lung disease (ILD) must be rooted in rigorous, high-quality research that is globally representative and inclusive. Objectives The objectives of this American Thoracic Society Statement are to emphasize the importance of racial, ethnic, sex, and gender considerations in ILD research; summarize existing evidence on differences and disparities in ILD care; and suggest practical recommendations to promote equitable inclusion in clinical research. Methods A multidisciplinary committee of experts in ILD, health equity, sex/gender, and race/ethnicity equity conducted a comprehensive review of the literature related to disparities in ILD. The group identified relevant studies pertaining to clinical trial participation and outcomes by race, ethnicity, sex, and gender. Consensus-based recommendations for equitable inclusion in research were developed through iterative discussion and agreement by all members. Main Results The review identified significant disparities across ILD domains, including epidemiology, diagnosis, management, treatment access, and clinical outcomes. Minority populations remain underrepresented in ILD research, especially in clinical trials of ILD treatment. Research efforts and programs in ILD must be based on inclusive practices. This can be accomplished by changing how subgroup data are collected, analyzed, and reported in ILD clinical trials, with greater attention to the inclusion of minority populations, at all levels of research. Conclusions Improving equity in ILD research is paramount to enhancing the generalizability and applicability of findings to the global ILD population. This goal will require coordinated action by all stakeholders, including researchers, institutions, funding agencies, and patient communities.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.559
metaresearch head score (Gemma)0.526
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Open science
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.991
Threshold uncertainty score0.544

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.5590.526
Meta-epidemiology (narrow)0.0020.003
Meta-epidemiology (broad)0.0050.009
Bibliometrics0.0090.009
Science and technology studies0.0110.022
Scholarly communication0.0190.020
Open science0.0090.020
Research integrity0.0240.036
Insufficient payload (model declined to judge)0.0070.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.160
GPT teacher head0.540
Teacher spread0.380 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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