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Role of childhood trauma in interoception and alexithymia in schizophrenia

2025· article· en· W4416867215 on OpenAlexaboutno aff
Samantha Narvaez, Krista Wisner, Alina Siatka, L. Elliot Hong, Joshua Chiappelli

Bibliographic record

VenueJournal of Psychiatric Research · 2025
Typearticle
Languageen
FieldMedicine
TopicPsychosomatic Disorders and Their Treatments
Canadian institutionsnot available
FundersNational Institute of Mental HealthNational Institutes of Health
KeywordsAlexithymiaCTQ treeToronto Alexithymia ScaleSchizophrenia (object-oriented programming)InteroceptionSchizoaffective disorderFeelingPsychosisChildhood abuse

Abstract

fetched live from OpenAlex

Childhood trauma (CT) is a notable risk factor for schizophrenia. Separately, CT has been associated with alexithymia, referring to difficulties in identifying and describing one's own feelings, as well as disturbed interoception, referring to difficulties sensing and responding to signals that originate from within the body. Both self-perception impairments have been observed in schizophrenia; however, the role of CT in these observations in schizophrenia is unclear. To address this gap, interoception was assessed using the Multidimensional Assessment of Interoceptive Awareness (MAIA), alexithymia was assessed using the Toronto Alexithymia Scale (TAS-20), and CT was measured using the Childhood Trauma Questionnaire (CTQ) in a sample of 73 patients with schizophrenia or schizoaffective disorder (SSD) and 50 healthy controls. Patients had higher TAS-20 total score compared to controls (F = 36.0, p < 0.001) but groups were not different on any of the MAIA subscales. Across the full sample, CTQ total score was correlated with MAIA "trusting" subscale (ρ = -0.26, p = 0.005), and with TAS total score (ρ = 0.22, p = 0.016). Moreover, the MAIA "trusting" relationship remained significant within the SSD group. CT is associated with decreased feelings of trust in bodily sensations in schizophrenia, similar to findings in other major psychiatric disorders.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.357
Teacher spread0.339 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes1
Has abstractno

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