Transport of Carbon Quantum Dots Across Bovine Blood Retina Barrier
Bibliographic record
Abstract
Tissue barriers limit the transport of drugs/imaging contract agents into the targeted site resulting in poor outcomes of diagnosis and therapeutic delivery. Carbon quantum dots (CQDs) have been applied as an alternative image contrast agent and theranostic carrier due to their special luminescent properties, versatile chemical modification, and good biocompatibility. The blood retina barrier (BRB) and the blood-brain barrier (BBB) has similar permeation and transport characteristics but is more readily available for study. Hence, this study investigates the transport of CQDs across the BRB using bovine eyes. CQD solution was added to the back of the bovine eye, and the photoluminescence in the neural retinal layer (NRL) and choroid layer (CL) before and after CQD treatment was measured. Under excitation (λ<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ex</inf>) at 430 nm, CQDs have a peak emission (λ<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">em</inf>) of 530 nm. In comparison, the NRL prior had no initial fluorescence. After treatment, there was one emission peak at 530 nm that corresponds with that of CQDs. In the CL, there were two pre-treatment emission peaks at 500 nm and 590 nm, with an additional peak at 530 nm after treatment. The results indicate that CQDs could cross the NRL into the CL and may have potential in crossing the BBB without any surface modification
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".