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Adding Acupuncture to Touch/Relaxation for Pain in Wartime: A Randomized Controlled Trial

2025· article· en· W4417164047 on OpenAlexaboutno aff
Eran Ben‐Arye, Jan Vagedes, Sameer Kassem, Noah Samuels, Ofer Lavie, Vika Zaritsky, Orit Gressel

Bibliographic record

VenueJournal of Pain and Symptom Management · 2025
Typearticle
Languageen
FieldMedicine
TopicAcupuncture Treatment Research Studies
Canadian institutionsnot available
FundersIsrael Cancer Association
KeywordsRandomized controlled trialAcupuncturePalliative careClinical trialChronic pain

Abstract

fetched live from OpenAlex

CONTEXT AND OBJECTIVES: Patients with cancer living in war zones face significant quality of life (QoL)-related challenges. This study examined an integrative oncology (IO) intervention in northern Israel for pain and autonomic response. METHODS: This prospective, randomized, controlled and pragmatic study examined an IO intervention with manual-relaxation, with acupuncture (Group A) or without (Group B). ESAS (Edmonton Symptom Assessment Scale), EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer QoL Questionnaire), and MYCAW (Measure Yourself Concerns and Wellbeing) tools were used to examine QoL. Heart rate and variability (HRV) were measured at baseline and 15 minutes post-treatment, comparing frequency-domain variable changes (e.g., LN Power Total, Power HF, Power LF, Power VLF). RESULTS: Of 125 patients, Groups A (67) and B (58) had similar demographic and cancer-related characteristics. ESAS pain scores improved in both groups post-treatment (A, P < 0.001; B, P = 0.002), as did anxiety, depression, and fatigue. At three weeks, Group B reported greater improvement on ESAS pain (P = 0.039) and MYCAW pain-related concerns (P = 0.025), both showing within-group improvement on EORTC pain. HRV showed greater change in Group A, with decreased LN Power Total (P = 0.006), LN Power LF (P = 0.02), and LN Power VLF (P = 0.026). While Relative Power HF increased marginally (P = 0.054), heart rate decreasing more significantly in Group B (P = 0.005). CONCLUSIONS: IO treatments led to reduced pain among patients with cancer living in a war zone, with no additive effect of acupuncture. HRV changes suggest enhanced parasympathetic activity, with acupuncture-treated patients showing additional frequency-domain changes attributed to decreased sympathetic tone.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.314
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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