Emerging Roles of CD1 and Lipids in Human Health and Disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Acting alongside MHC proteins, which present peptide antigens, the CD1 system displays lipid antigens to T cells. Recent studies have defined two general mechanisms of T cell receptor (TCR) binding to human CD1a, CD1b, CD1c, and CD1d proteins. The classical mechanism involves TCR corecognition of lipid antigens and CD1 proteins. In the second mechanism, however, other αβ and γδ TCRs directly recognize the surface of CD1 in a lipid-independent manner, which partially bypasses the need to identify lipid autoantigens in disease states. In this article, we review the development of new experimental tools such as cell-wide lipidomic investigation of self-lipids, endogenously loaded CD1 tetramers, and human CD1 transgenic mice. These tools are revealing nonredundant roles for CD1 in immune response and are providing evidence that CD1-reactive T cells participate in disease lesions in human skin and gut. Further, the unexpected discovery of lipid blockers of CD1-TCR interaction supports new approaches to immunomodulation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it