70 Diagnostic Value of the MaRIA Index and its Correlation With Clinical and Biochemical Parameters in Patients With Crohn’s Disease in a Tertiary Care Hospital in Mexico
Bibliographic record
Abstract
Introduction: Crohn’s disease (CD) is a chronic, transmural inflammatory disorder that may lead to stenosis, fistulas, and abscesses. Ileocolonoscopy is the gold standard for mucosal assessment, but its repeated use is limited by its invasive nature. Magnetic Resonance Index of Activity (MaRIA) provides a non-invasive evaluation of inflammatory activity. Correlating MaRIA with clinical indices and biomarkers may optimize disease monitoring, particularly in resource-limited settings. Aim: To determine the correlation between MaRIA index and clinical/biochemical parameters—Harvey–Bradshaw Index (HBI), Crohn’s Disease Activity Index (CDAI), C-reactive protein (CRP), and fecal calprotectin (FC)—in patients with CD at a tertiary care center in Mexico. Methods: A retrospective, observational, analytical study was conducted in 46 patients with CD treated at the Inflammatory Bowel Disease Clinic of the Hospital General de México. Data collected included enterography findings (MaRIA index), clinical indices, and biomarkers. Distribution was assessed using the Shapiro–Wilk test; correlations were evaluated using Spearman’s rank test. ROC curves were constructed to assess the discriminative ability of MaRIA for clinical remission. Analyses were performed with SPSS v29. Results: Clinical and demographic characteristics are summarized in Table 1 [presented in poster]. The mean age was 47.5 years, and 58.7% were women. According to the Montreal classification, L3 location predominated (41.3%), and A2–A3 age groups were most frequent (47.8%). Extraintestinal manifestations were observed in 47.8%, and perianal disease in 28.3%. Biologic therapy was used by 78.3%, predominantly ustekinumab (52.2%). During follow-up, 45.7% were hospitalized and 41.3% required surgery. MaRIA showed a significant positive correlation with HBI (rho = 0.525, P = 0.0021) and CDAI (rho = 0.522, P = 0.0022), but no association with CRP (rho = 0.293, P = 0.1037) or FC (rho = 0.053, P = 0.7721). ROC analysis showed an AUC of 0.750 for HBI and 0.821 for CDAI, indicating good discriminative ability for identifying clinical activity. Conclusions: The MaRIA index demonstrated significant correlation with clinical indices (HBI and CDAI) but not with biochemical biomarkers. These findings suggest that MaRIA may represent a reliable, non-invasive tool for assessing inflammatory activity in CD, particularly valuable in settings with limited resources.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".