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Record W4417178220 · doi:10.1016/j.epidem.2025.100878

Insights from a Ventilation-Aware Pandemic and Outbreak Risk model (VAPOR)

2025· article· en· W4417178220 on OpenAlex
Natalie Wilson, Callandra Moore, Eunyoung Lee, Ashleigh R. Tuite, David N. Fisman

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueEpidemics · 2025
Typearticle
Languageen
FieldMedicine
TopicInfection Control and Ventilation
Canadian institutionsPublic Health Agency of CanadaPublic Health OntarioUniversity of Toronto
FundersCanadian Institutes of Health Research
KeywordsPandemicOutbreakTransmission (telecommunications)Airborne transmissionBaseline (sea)Ventilation (architecture)

Abstract

fetched live from OpenAlex

Transmission of airborne pathogens in indoor spaces is strongly modulated by heterogeneity in ventilation. Understanding the role indoor air plays in pandemic risk is limited in part due to differing modeling approaches used in engineering and epidemiology. Here we present the VAPOR (Ventilation-Aware Pandemic and Outbreak Risk) model, a hybrid transmission framework that integrates Reed-Frost close-contact dynamics with Wells-Riley aerosol-mediated risk. Using a meta-population structure to simulate multi-patch environments (e.g., separate workplaces or schools), we explore how ventilation disparities shape epidemic potential. A fixed minority of individuals are modeled as "aerosolizers," consistent with overdispersed real-world transmission patterns (e.g., SARS-CoV-2). Simulations reveal that both improving ventilation in high-risk patches and raising baseline ventilation across environments independently reduces risk. Parameter sweeps across air changes per hour (ACH, 2-12) demonstrate non-linear benefits with early saturation. These findings emphasize the need for targeted ventilation strategies and show how small-world effects amplify heterogeneity-driven transmission. VAPOR offers a framework for linking ventilation equity to epidemic control.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.632
Threshold uncertainty score0.385

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.292
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it