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Living Rapid Research Needs Appraisal (RRNA) for Priority Diseases Protocol

2025· article· en· W4417200994 on OpenAlexfundno aff
Marieke de Swart, Dijana Spasenoska, Eli Harriss, Katrin Probyn, Gemma Villanueva, Thomas Mendy, Musawenkosi Ndlovu, Brian S Buckley, Daniela Toale, Nicholas Henschke, Duduzile Ndwandwe, Alice Norton, Louise Sigfrid

Bibliographic record

VenueWellcome Open Research · 2025
Typearticle
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsnot available
FundersNational Institute for Health and Care ResearchUK Research and InnovationInternational Development Research CentreWellcome Trust
KeywordsProtocol (science)PandemicSystematic reviewPreparednessContext (archaeology)Critical appraisalPublic healthRelevance (law)

Abstract

fetched live from OpenAlex

<ns5:p>Systematic reviews require time and resources to conduct that might not be available in a rapidly developing context such as during new and (re-) emerging infectious disease outbreaks. As part of the Pandemic-PACT program at the Pandemic Sciences Institute at the University of Oxford we have, in collaboration with Cochrane Response and Cochrane South Africa, developed a "living" Rapid Research Needs Appraisal (RRNA) methodology. The aim is to develop a protocol for rapidly and robustly identify key evidence gaps across pre-defined research domains to inform research prioritisation and coordination in preparedness time and during outbreaks. The RRNA utilises modified systematic review methods, a global relay of reviewers, and systematic review software. The objective is to strengthen capability for carrying out RRNAs, and establish a baseline evidence platform for priority infectious diseases that can be readily updated as new evidence emerges, utilising an adaptable "living" RRNA protocol. This data will be of relevance to funders, researchers, clinical and public health stakeholders involved in management of infectious diseases of epidemic and pandemic potential.</ns5:p>

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.525
metaresearch head score (Gemma)0.247
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Science and technology studies, Scholarly communication, Open science, Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch, Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.279
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.5250.247
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0030.012
Science and technology studies0.0020.001
Scholarly communication0.0120.001
Open science0.0150.006
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0240.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.904
GPT teacher head0.708
Teacher spread0.196 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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