Updates in Allergic Bronchopulmonary Aspergillosis
Bibliographic record
Abstract
Allergic Bronchopulmonary Aspergillosis (ABPA) is a complex lung disorder that results from a hypersensitivity reaction to the fungus Aspergillus fumigatus following airway colonization in patients with chronic lung diseases. ABPA predominantly affects patients with asthma and cystic fibrosis, though it can occur in other bronchiectatic conditions. Worldwide, APBA is estimated to impact over four million people. The pathogenesis of APBA involves both type I and type III hypersensitivity reactions, creating a distinctive inflammatory cascade dominated by T-helper 2 (Th2) lymphocytes and eosinophils. This immune dysregulation leads to recurrent mucoid impaction, progressive bronchiectasis, and, if left untreated, irreversible lung damage. As our understanding of ABPA pathophysiology has evolved, therapeutic approaches have advanced significantly, with biologic therapies offering promising steroid-sparing alternatives for refractory or steroid-dependent diseases.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".