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Record W4417429148 · doi:10.1038/s43246-025-01007-7

Meta-analyses of the evolution of MXene synthesis for bioengineering and artificial intelligence-driven applications

2025· article· en· W4417429148 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueCommunications Materials · 2025
Typearticle
Languageen
FieldMaterials Science
TopicMXene and MAX Phase Materials
Canadian institutionsSt. Boniface Hospital
FundersNatural Sciences and Engineering Research Council of CanadaGovernment of Canada
KeywordsMXenesTransformative learningCharacterization (materials science)Key (lock)Etching (microfabrication)

Abstract

fetched live from OpenAlex

The year 2011 marked a breakthrough in material science innovation with the discovery of MXenes, an emerging family of two-dimensional transition metal-based nanomaterials. Owing to their distinctive properties, MXenes have rapidly surfaced as transformative materials, particularly in energy-storage and nanomedicine. In this review, we systematically explore the evolution of MXene synthesis, from its discovery to current advancements, focussing on their bioengineering applications, through a meta-analytic and bibliometric lens. We discuss synthesis methods, ranging from hydrofluoric acid (HF)-based etching to non-HF approaches, along with post-synthesis processes like intercalation, delamination and surface functionalization, that tailor MXene properties for biomedical therapeutics. We also overview key microscopy, spectroscopy and diffraction-based characterization methods, to understand their structure and functionality. Additionally, discussion on artificial intelligence (AI)-driven innovations highlights the significant shift in material science. By connecting synthesis methods with resulting characteristics and meta-analyses trends, this review emphasizes MXenes' transformative potential in regenerative therapeutics and diagnostics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.279
Threshold uncertainty score0.334

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.225
GPT teacher head0.388
Teacher spread0.163 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it