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Record W47086672 · doi:10.26443/mjm.v6i1.559

The Role of Testosterone in Aggression

2020· article· en· W47086672 on OpenAlexvenueno aff
Katherine Simpson

Bibliographic record

VenueMcGill Journal of Medicine · 2020
Typearticle
Languageen
FieldMedicine
TopicHormonal and reproductive studies
Canadian institutionsnot available
Fundersnot available
KeywordsAggressionTestosterone (patch)AndrogenAndrogen receptorEndocrinologyArousalInternal medicineEstrogenDihydrotestosteroneMedicineNeurosciencePsychologyDevelopmental psychologyHormone

Abstract

fetched live from OpenAlex

This review article explores the evidence that testosterone is significantly correlated with certain forms of aggression in a number of animals, although firm evidence is lacking for humans. Studies have revealed that structures within the limbic system are particularly involved in the elicitation of aggression and are sexually dimorphic. Testosterone can exert its effects in one of two ways: either on androgen receptors after conversion to 5-alpha dihydrotestosterone or on estrogen receptors after aromatization to estradiol. It can act via genomic mechanisms to induce production of proteins or via non genomic mechanisms to modulate neural activity. Androgen and estrogen receptors are also found along neurotransmitter pathways. As such, testosterone is able to modulate levels of various neurotransmitters that show evidence of mediating effects on aggressive behaviour. In addition, recent evidence suggests that these neurotransmitters are involved in processes such as olfaction and arousal and suggestions have been put forward explaining how testosterone may modulate these processes. However there is a critical time period early in life, usually within the first few days after birth, during which testosterone exposure is essential to elicit aggression in adulthood. It is thought that testosterone and its metabolites sensitize an androgen-responsive system, while estrogenic metabolites establish the capacity to fight in response to estrogenic stimulation later in life. Despite this, testosterone is only one of a myriad of factors that influence aggression and the effects of previous experience and environmental stimuli have at times been found to correlate more strongly.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.596
Threshold uncertainty score0.137

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.290
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations54
Published2020
Admission routes1
Has abstractyes

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