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Record W471273204 · doi:10.1086/432452

Eclipse of the Gene and the Return of Divination

2005· article· en· W471273204 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCurrent Anthropology · 2005
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRace, Genetics, and Society
Canadian institutionsMcGill University
Fundersnot available
KeywordsDiseaseMendelian inheritanceHeredityGeneticsBiologyHuman geneticsGenetic epidemiologyPopulationEvolutionary biologySociologyMedicineGeneDemography

Abstract

fetched live from OpenAlex

Research in the field of epigenetics challenges the assumption on which the molecular genetics of the past 50 years has been based, namely, genetic determinism. This paper reviews the social science literature that considers the social effects of the application of molecular genetics and genetic testing in connection with Mendelian conditions. It is argued that anthropologists must now go farther and respond to the challenge posed by current moves toward the implementation of genetic profiling and testing for susceptibility genes. Following a discussion of ontological problems associated with molecular genetics raised by philosophers and biologists who subscribe to epigenetics, current knowledge about molecular and population genetics of lateonset Alzheimers disease and crosscultural findings about the epidemiology of this disease are introduced. These findings illustrate the provisional nature of these bodies of knowledge and the complexity associated with susceptibility genes, which makes estimations of probabilities of individual risk unrealistic. A controlled clinical trial is discussed in which firstdegree relatives of Alzheimers disease patients are genotyped for risk for lateonset Alzheimers disease. In conclusion, the social implications of testing for susceptibility genes are discussed, with comments about the role that anthropologists might play in future research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.134
Threshold uncertainty score0.710

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.287
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it