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Record W53234381

Ethics of Stem-Cell Research: A Framework for Ethical Dialogue regarding Sources of Conflict

2007· article· en· W53234381 on OpenAlexaboutno aff
Francis C. Dane, James V. Finkbeiner

Bibliographic record

VenueForum on public policy · 2007
Typearticle
Languageen
FieldMedicine
TopicEthics and Legal Issues in Pediatric Healthcare
Canadian institutionsnot available
Fundersnot available
KeywordsEthical dilemmaValue (mathematics)Environmental ethicsPolitical scienceSociologyEpistemologyLawPhilosophy
DOInot available

Abstract

fetched live from OpenAlex

Introduction One need hardly point out that Darwin's (1859) Origin produced controversy from its first appearance. Equally obvious is fact that, however much value scientists place on evolutionary theory as an explanatory mechanism, theory remains controversial outside of scientific circles and within nearly every venue in which scientific circles overlap with other areas of inquiry. The controversy exceeds even that of Galileo's (1632/1967) heliocentric viewpoint in his Dialogue, prompting Stephen Gould to claim controversy has reached point at which the very integrity of education hangs in balance (Alters and Alters 2001, p. 1). Indeed, evolution may well be only scientific theory about which scientists have felt compelled to write book to inform educators about how to deal with a war within scientific classrooms (Alters and Alters 2001, p. 14). Public attitudes about evolution, similar to those concerning abortion and capital punishment, have become polarized such that most people hold position that allows little latitude for rational consideration of informational contrary to their position (beaux, Dane, and Wrightsman 1993). The purpose of present paper is to present framework for discussing ethics of stem-cell research in hopes of preventing its joining ranks of polarized attitudes. I do not wish to imply that stem-cell research is not yet controversial. Indeed, variety of governmental positions on various types of stem-cell research provides but one indication of extent to which disagreements exist within worldwide community, and sometimes with single nation. The General Assembly of United Nations failed to reach agreement on treaty regarding somatic cell nuclear transfer, also known as SCNT (Caulfield and von Tigerstrom 2005). Caulfield and Bubela (2007) report that Ireland and Austria forbid any research involving embryos while Italy is moving toward similar ban. United Kingdom, Japan, Sweden, and South Korea, in contrast, allow virtually all types of stem-cell research, while France and Canada allow some types of stem research; SCNT was, however, recently made criminal activity in Canada. The President of United States froze embryonic stem-cell research funding, including SCNT (Bush 2001), after which California voters responded by approving $3 billion bond to fund fetal stem-cell research, including SCNT (Californians approve stem cell research funding 2004). Aramesh (2007) reports that Iran permits stem-cell research, including SCNT, and notes that Muslim scholars prohibit only research directed toward reproductive cloning. (The latter position is in line with virtually all bioethicists.) These disagreements notwithstanding, most political jurisdictions have no explicit policy regarding stem-cell research; in all jurisdictions, absence of framework for dialogue prevents many from considering rationally ethical aspects of stem-cell research. If we are to reach consensus regarding ethics of stem-cell research, we must have single framework, common language with which to discuss differences. It is important that any framework for discussing propriety of stem-cell research be presented at conceptual or principled level. Ethical discussions are not about whether or not rule or law has been broken; such are moral, legal, or administrative decisions. Instead, ethical discussions are about whether or not rule or standard is worthwhile or about which of several, incompatible rules should be given priority (e.g., Dane and Parish 2006; Schroeder 2000; Singer 2000). As has been illustrated, rules can change from one jurisdiction to another or, as noted below, from one set of religious rules to another. Principles, in contrast, tend to be more generalizable, more applicable to wider variety of situations, locations, and topics. Consider, for example, variety of religious positions regarding beginning of human life, which range from conception to an infant's first cry to as long as several years after birth (Morowitz and Trefil 1992). …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.043
metaresearch head score (Gemma)0.022
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.043
Threshold uncertainty score0.229

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0430.022
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.003
Science and technology studies0.0120.086
Scholarly communication0.0230.018
Open science0.0050.010
Research integrity0.0230.012
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.246
GPT teacher head0.496
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2007
Admission routes1
Has abstractyes

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