Pressor and renal haemodynamic responses to angiotensin II (ANG II) in conscious lambs: Role of nitric oxide (NO) and prostaglandins (PGs)
Bibliographic record
Abstract
Previously, we showed in conscious lambs that pressor and renal haemodynamic responses to ANG II were greater at ∼six weeks as compared to newborns aged ∼one week. The present study investigated the roles of NO and PGs in modulating these responses to ANG II during post natal maturation. Two experiments were carried out at an interval of 24 h in two age groups of conscious, chronically instrumented lambs: ∼one week (N=8) and ∼six weeks (N=10). Acute arterial pressure (AP) and renal blood flow (RBF) responses to intra‐venous (I.V.) injection of EC 50 ANG II were tested before and after administration of the L‐arginine analogue, N G ‐nitro‐L‐arginine methyl ester (L‐NAME), in the presence of either vehicle (veh, experiment one) or indomethacin (indo, experiment two). In both age groups, L‐NAME had no effects on the AP and RBF responses to ANG II after veh. In contrast, after indo, AP and RBF responses to L‐NAME were increased at one week but not at six weeks. Therefore, there is an age‐dependent interaction between NO and PGs in buffering the pressor and renal haemodynamic effects of ANG II soon after birth.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".