Compatibility Assessment of Closed-system Device "PhaSeal SOLUS" and Antineoplastic-agent Vials
Why this work is in the frame
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Bibliographic record
Abstract
The use of closed systems is recommended to prevent occupational exposure to anti-cancer agents during preparation.The PhaSeal closed-system consists of an“Injector”and a“Protector”.Named“SOLUS”,the Protector can be used with reconstitution drug vials as well as drug solution vials.We therefore studied the compatibility of SOLUS and 41 kinds of reconstitution drug,as well as durability.After attaching SOLUS to the vials,needle insertion was performed 10 times by the Injector.Thereafter,they were injected with a mixture of distilled water and sodium fluorescein (FL-Dw) under pressurization.Immediately afterwards,after 1 hour and 24 hours,the vials were examined under UV light to determine whether there was any liquid leakage following injection of FL-Dw,and then the same test was performed without pressurization.Next,“Protector P 21”or SOLUS was attached to the vials and FL-Dw was injected into them.Needle insertion was then performed 30 times under both pressurized and unpressurized conditions and vials were examined under UV.The surface or membrane of SOLUS was determined to be fluorescent for 10 kinds of vial tested.Five types of vial were excluded because their diameter did not match the apparatus.Under unpressurized conditions,the apparatus could be used safely for needle insertion by P 21 or SOLUS up to 30 times.However,when vials required pressurization,inserting the needle 5 times caused leakage.Twenty-six kinds of reconstitution drug vial could be used safely with SOLUS.However,there is still the possibility of exposure to anti-cancer drugs due to leakage and SOLUS should therefore be operated carefully.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it