Immune reactivity to a homologue of wheat storage globulin, Glb1 in human type 1 diabetes
Bibliographic record
Abstract
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease dependent on gene‐environment interaction. A wheat storage globulin with 80% amino acid homology to Glb1 (referred to as Glb1), was identified as the first candidate diabetes‐related wheat protein in diabetes‐prone rats. Glb1 antibodies were also found in pooled diabetic serum (MacFarlane et al ., JBC, 2003). In this study, we evaluated the response of peripheral blood T cells to recombinant Glb1 protein in T1D patients and healthy controls. T cell response was measured using a CFSE proliferation assay and reported as cell division index (CDI). Th1 and Th2 cytokines were analyzed using cytometric bead arrays. Glb1 antibodies were evaluated by ELISA. T1D patients showed a higher mean CDI in response to Glb1. More than 1/3 of patients were responders (CDI > control mean + 3 SD). Cytokine analysis of the culture supernatant from Glb1‐stimulated PBMC of patients showed a Th1 response, with IFN‐γ most abundant. Approximately 25% of patients displayed Glb1 antibody levels higher than the control group mean + 2 SD. This study demonstrates high T cell reactivity with a Th1 response and antibodies to Glb1 in a subset of T1D patients. Further study is required to determine whether Glb1 plays a direct role in the pathogenesis of T1D or whether immune reactivity against this protein is a biomarker of a related process. (Supported by JDRF and CIHR)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".