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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Bibliographic record
VenueApollo (University of Cambridge) · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsnot available
FundersMedical Research and Materiel CommandNIH Office of the DirectorServicio Gallego de SaludInstituto de Salud Carlos IIICancer Council Western AustraliaCancer Council NSWCancer Council VictoriaWorld Cancer Research FundEuropean Social FundMedical Research CouncilEuropean CommissionCanadian Institutes of Health ResearchDivision of Cancer Prevention, National Cancer InstituteNational Institutes of HealthHellenic Health FoundationFreistaat SachsenCentro de Investigación Biomédica en Red de CáncerFederal Agency for Scientific OrganizationsDeutschen Konsortium für Translationale KrebsforschungUniversitätsklinikum Hamburg-EppendorfDr. Ralph and Marian Falk Medical Research TrustXunta de GaliciaMutuelle Générale de l'Education NationaleKWF KankerbestrijdingFox Chase Cancer CenterMinistero dello Sviluppo EconomicoCancer Council South AustraliaIstituto Oncologico VenetoMemorial Sloan-Kettering Cancer CenterCentre International de Recherche sur le CancerInstitut National Du CancerNational Health and Medical Research CouncilDeutsche KrebshilfeVetenskapsrådetStockholms Läns LandstingKuopion Yliopistollinen SairaalaAssociazione Italiana per la Ricerca sul CancroKarolinska InstitutetMcGill UniversityGeneralitat de CatalunyaCancer Center, University of KansasUniversity of Southern CaliforniaCancerfondenCancer Council TasmaniaItä-Suomen YliopistoEberhard Karls Universität TübingenAmerican Cancer SocietyCancer AustraliaRussian Foundation for Basic ResearchUniversity of CreteMinistero della SaluteInstitut National de la Santé et de la Recherche MédicaleDeutsche Gesetzliche UnfallversicherungNederlandse Organisatie voor Wetenschappelijk OnderzoekGentofte HospitalDeutsche ForschungsgemeinschaftRobert Bosch StiftungU.S. ArmyLigue Contre le CancerUniversity of WestminsterUniversity College LondonCancer Institute NSWHospital de Câncer de BarretosNational Cancer InstituteEuropean Regional Development FundMinisterio de Sanidad, Servicios Sociales e IgualdadGovernment of CanadaStavros Niarchos FoundationUniversity of PennsylvaniaFondation de FranceGeorgetown UniversityBreast Cancer CampaignNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchNational Breast Cancer FoundationAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du TravailSwedish Cancer FoundationUniversity of California, IrvineNewcastle UniversityDavid F. and Margaret T. Grohne Family FoundationSundhed og Sygdom, Det Frie ForskningsrådDeutsches KrebsforschungszentrumMinistère du Développement Économique, de l’Innovation et de l’ExportationLon V. Smith FoundationFundación Mutua MadrileñaCalifornia Department of Public HealthGenome CanadaJewish General HospitalNational Institute for Health and Care ResearchBreast Cancer Research FoundationUniversity of ChicagoNRG OncologyFondation du cancer du sein du QuébecKansas Bioscience AuthorityInstitut Català de la SalutInstitut Gustave-RoussyCancer Research UKBeckman Research Institute, City of HopeSusan G. Komen for the CureBeth Israel Deaconess Medical CenterFundación CellexFisher Center for Alzheimer's Research FoundationRheinische Friedrich-Wilhelms-Universität BonnUniversitair Medisch Centrum GroningenOak FoundationOhio State UniversityRoyal Marsden NHS Foundation TrustUniversity of California, San FranciscoU.S. Department of Health and Human ServicesAgence Nationale de la RechercheMinisterio de Economía y CompetitividadNational Center for Advancing Translational SciencesBundesministerium für Bildung und ForschungOvarian Cancer Research FundFonds Wetenschappelijk Onderzoek
KeywordsMutationBreast cancerGenotypePopulationCancerGenetic associationGeneMutation testing
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.546
Threshold uncertainty score0.738
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.016
GPT teacher head0.270
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations0
Published2020
Admission routes1
Has abstractno