1,4-Diazepinone and Pyrrolodiazepinone\nSyntheses via Homoallylic Ketones from\nCascade Addition of Vinyl Grignard\nReagent to α-Aminoacyl-β-amino Esters
Bibliographic record
Abstract
1,4-Diazepinones <b>5</b> and pyrrolodiazepinones <b>8</b> and <b>9</b> were synthesized from common homoallylic ketone precursors<b> 4</b> prepared by copper-catalyzed cascade addition of a vinyl Grignard reagent to α-aminoacyl β-amino esters <b>3</b>. Nitrogen deprotection and intramolecular reductive\namination yielded 1,4-diazepinones <b>5</b>. Olefin oxidation, Boc removal, and intramolecular Paal−Knorr condensation gave pyrrolodiazepinones\n<b>8</b> and <b>9</b>. X-ray structures of diazepinones <b>5c</b> and <b>5d</b> depicted dihedral angles about the α-amino acid moiety similar to those of the central\nresidue in an ideal reverse γ-turn.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.248 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".