Stress in adolescence alters guidance cue pathways and impacts dopamine development
Why this work is in the frame
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Bibliographic record
Abstract
Authors: Cecilia Flores¹ ¹McGill University Abstract: Dopamine (DA) connectivity in the prefrontal cortex (PFC) continues to unfold until early adulthood, with dramatic organizational and functional changes occurring during adolescence. This delayed development involves long-distance axonal growth of midbrain DA neurons across the adolescent period and is mediated by the Netrin-1/DCC guidance cue pathway. We examined whether repeated social stress in adolescence dysregulates the Netrin-1/DCC pathway, disrupting PFC DA innervation and cognitive control in adulthood. We used a modified accelerated social defeat stress (ASD) model and segregated mice into resilient (RES) and susceptible (SUS) groups by measuring social avoidance in a social interaction test (SIT) 24h after ASD exposure. ASD in adolescence downregulates DCC expression in DA neurons in SUS and RES groups, but its effects on PFC DA development and behavior differ between phenotypes. ASD-induced molecular, cellular and behavioral changes are not observed following ASD exposure in adulthood. While most (~60%) mice exposed to adolescent ASD show RES, most adult mice show stress SUS. Alterations in dopamine development in adolescence may mediate the established link between genetic variance within the Netrin-1/DCC pathway and psychiatric disorders of neurodevelopmental origin.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it