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Record W6912960022 · doi:10.5451/unibas-ep88089

The genomic basis of adaptation in threespine stickleback fish

2020· article· en· W6912960022 on OpenAlexaboutno aff

Bibliographic record

Venueedoc (University of Basel) · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic diversity and population structure
Canadian institutionsnot available
Fundersnot available
KeywordsSticklebackAdaptation (eye)Fish <Actinopterygii>GasterosteusPopulation

Abstract

fetched live from OpenAlex

Evolutionary biology consists in the study of the evolutionary processes responsible of the diversification and adaptation of life forms over time. When adapting to a new environment (or changes in their local environment), populations have to adapt through natural selection. Until recently, the study of adaptation was focusing on fathoming the consequences of natural selection at the phenotypic level and how phenotypic evolution is linked to genetic changes. The development of new genetic and genomic tools in the last 20 years, like high-throughput sequencing technologies, now allows the construction of reference genomes in a variety of non-model organisms and the investigation of the genomic basis of adaptation. In my thesis, I investigated the genomic basis of adaptation by exploring the consequences of natural selection at the molecular level using the threespine stickleback fish (Gasterosteus acualeatus) as a model.&#13;\nIn more detail, my work focused on three main topics: the genomic basis of parallel adaptation to acidic versus basic lochs of North Uist (Outer Hebrides, Scotland); the maintenance of standing genetic variation in Atlantic stickleback fish, and the characterization of reproductive isolation at the genomic level between parapatric stickleback populations of the Misty watershed (Vancouver Island, British Columbia, Canada).&#13;\n

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.623
Threshold uncertainty score0.210

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.184
Teacher spread0.170 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

Explore more

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