Additional file 1 of Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI
Bibliographic record
Abstract
Additional file 1: Fig. S1. Three-dimensional rendering of the ROIs used to reconstruct the three subdivisions of the cingulum bundle superimposed in the Montreal Neurological Institute space represented as a surface. ROI 1 (violet) and ROI 2 (teal) were used for the reconstruction of the subgenual subdivision as seed and “include” mode, respectively; ROI 3 (red) and ROI 4 (green) were used for the reconstruction of the retrosplenial subdivision as seed and “include” mode, respectively; ROI 5 (blue), ROI 6 (pink for the left hemisphere and yellow for the right hemisphere), and ROI 4 were used to reconstruct the parahippocampal subdivision as seed, “exclude”, and “include” mode, respectively. ROI Region of interest. Fig. S2. Orthogonal view of the thresholded (at 1%) overlap of the subdivisions of the cingulum bundle for the five middle-aged cognitive normal case (average representation): subgenual in cyan-blue color map (a); retrosplenial in red-yellow color map (b); and parahippocampal in light-dark green color map (c). The intensity scales are percentages associated to the minimum and maximum of the subjects represented by the overlap of the tracts. Fig. S3. (a) Example of axial views of diffusion-weighted images (b = 0 s/mm2) before distortion correction; distortions are evident especially in the frontal part of the brain. (b) The same axial view after Synb0-DISCO application and distortions correction, showing the frontal part of the brain restored. (c) The difference between a and b showing at a first glance, regions were the Synb0-DISCO have mostly corrected the distortions. Table S1. Coordinates of the center of gravity of the six ROIs and the midsagittal ROI used to reconstruct the subgenual, retrosplenial, parahippocampal subdivision of the cingulum bundle are reported in standard Montreal Neurological Institute space for both hemispheres. Table S2. Three-way ANOVA results for four NODDI metrics: tissue volume fraction, β-fraction, neurite dispersion index, and orientation dispersion index. Table S3. Post hoc analyses for group differences performed by the Tukey’s HSD test applying the Benjamini–Hochberg correction for the adjusted p-values. Table S4. Post hoc analyses for subdivision differences performed by the Tukey’s HSD test applying the Benjamini–Hochberg correction for the adjusted p-values.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.025 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.860 | 0.137 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".