Familial occurrence of artefactual ocular hypertension from thick corneas and of primary open angle glaucoma in a French Canadian kindred
Bibliographic record
Abstract
We describe the coexistence of artefactual ocular hypertension due to increased central corneal thickness (CCT>585 microm), with primary open angle glaucoma (POAG) in a French Canadian kindred. Seventeen members of the family were examined and classified as to their glaucoma status. The mean CCT for our glaucoma patients (580 microm; n=5) and that for normals (552 microm; n=6) were within two standard deviations of the mean value provided in the literature (531 microm +/- SD=29 microm). The mean CCT of 611 microm for the suspect group (n=6) was considerably higher than for the glaucoma and normal groups. All but one of the suspects were classified as ocular hypertensives on the basis of high intraocular pressures (IOPs). When the IOPs for these patients (mean 22.6 mmHg) were corrected for their CCTs, all had pressures of(mean 16.4 mmHg). Ten of the seventeen family members had thick CCTs, and transmission of thick corneas was seen in two generations. A number of individuals in this family had optic nerve head drusen (9/17) and the mean CCT of these individuals (601 microm) was higher than the mean CCT (560 microm) of the group without drusen (P=0.020 by t test). Artefactual ocular hypertension and POAG can be present in different members of the same family. The presence of a thick cornea appears to be an inherited trait and may be associated with the presence of optic nerve drusen. This association suggests a developmental relationship between thick corneas and optic nerve head drusen which needs to be studied further.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".