Chemical Composition\nand Antiplasmodial Activity of\nthe Essential Oil of <i>Rhododendron subarcticum</i> Leaves\nfrom Nunavik, Quebec, Canada
Why this work is in the frame
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Bibliographic record
Abstract
Dwarf Labrador tea, Rhododendron subarcticum Harmaja, is a popular medicinal\nplant in use by First Nations of\nNorthern Canada, but its phytochemistry has remained largely unexplored.\nWe have isolated and characterized the essential oil from a population\nof this species harvested near the treeline in Nunavik, Québec.\nAnalyses by gas chromatography–mass spectrometry (GC–MS)\nand gas chromatography/flame-ionization detection (GC/FID) led to\nthe identification of 53 compounds; the main secondary metabolites\nwere ascaridole (64.7% of the total FID area) and <i>p</i>-cymene (21.1%). Such a composition resembles a chemotype observed\nfor R. tomentosum, a close relative\nfound mainly in Europe and Asia, but has never been attributed to R. subarcticum. Growth inhibition assays against\ndifferent strains of Plasmodium falciparum (3D7, Dd2), the parasite responsible for the most severe form of\nmalaria, were conducted with either the R. subarcticum’s essential oil or the isolated ascaridole. Our results show\nthat the essential oil’s biological activity can be attributed\nto ascaridole as its IC<sub>50</sub> is more than twice that of ascaridole\n[ascaridole’s IC<sub>50</sub> values are 147.3 nM (3D7) and\n104.9 nM (Dd2)].
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it