Additional file 1 of Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study
Bibliographic record
Abstract
Additional file 1: Fig. S1. Flowchart of sample selection and analysis steps in this study. Fig. S2. Pairwise Pearson correlation coefficient heat map of fasting glucose, 2-h post-load glucose, fasting insulin, HOMA-IR and HbA1c. Fig. S3. Histograms and pair-wise scatter plots of fasting glucose and 2-h post-load glucose concentrations at preconception, pregnancy and postpartum using trio subjects. Fig. S4. Histograms and pair-wise scatter plots of fasting insulin concentration and HOMA-IR at preconception, pregnancy and postpartum using trio subjects. Fig. S5. Histograms and pair-wise scatter plots of glycated haemoglobin (HbA1c, %) at preconception, pregnancy and postpartum using trio subjects. Fig. S6. Forest plots of fasting glucose concentration at postpartum, 2-h post-load glucose concentration at preconception, and HbA1c level at preconception, pregnancy and postpartum. Fig. S7. Scatter plots of effect sizes at preconception, pregnancy and postpartum in the fasting glucose, 2-h post-load glucose, fasting insulin, HOMA-IR association studies. Fig. S8. Venn diagrams of significant lipid species at preconception, pregnancy and postpartum for fasting glucose concentration, 2-h post-load glucose concentration and GDM status based on nominal p-value cut-off and the profiles of six selected lipid species from the 37 preconception signatures of GDM. Fig. S9. Association results of plasma fasting insulin concentration with plasma lipidomic profiles at preconception, pregnancy and postpartum. Fig. S10. Association results of fasting glucose, 2-h post-load glucose, impaired glucose tolerance status, fasting insulin, HOMA-IR and HbA1c levels at preconception. Fig. S11. Scatter plots of effect sizes in the association results of fasting glucose, 2-h post-load glucose, fasting insulin and HOMA-IR at preconception using trio and all subjects. Fig. S12. Percentage of individual lipid species within phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol classes. Fig. S13. Lipid ratios for enzyme indices of phosphatidylethanolamine n-methyltransferase (PEMT), lecithin-cholesterol acyltransferase (LCAT) and phospholipase A2 (PLA2).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.028 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.766 | 0.073 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".