Efficacy of Intraarticular Knee Injection of PRP (Platelet Rich Plasma) vs Steroid (Triamcinolone Acetate) for the Treatment of Primary Knee Osteoarthritis Grade I & II.
Bibliographic record
Abstract
Background & Objective: Knee osteoarthritis (OA) is a degenerative process of the bones and the articular cartilages that gradually erodes the joint and its surrounding structures. Plasma proteins have a positive impact on the cartilage repair and it helps them in regrowth. Cartilage healing helps in reducing pain and stiffness and enhancing functional activities in the patients with degenerative knee osteoarthritis. Intra-articular steroid injection are widely given with a belief that these will arrest the degenerative process. We conducted this study to assess the effectiveness of platelet rich plasma and to compare with steroid (triamcinolone 40mg) on pain, stiffness and functional activity in Grade I & II knee OA. Methodology: A randomized experimental trial was conducted at outdoor departments of pain medicine, rheumatology and orthopedics of Pain Clinic, Ghurki Trust Teaching Hospital Lahore (Pakistan) from January 2022 to December 2022. A total of 190 consecutive patients were taken after meeting inclusion criteria, 45 dropped not meeting inclusion criteria and approval from the ethical committee. Among 190 patients, 64(33%) patients were male and 126(67%) patients were female. The mean age of participants was 53.5 ± 6.4 y. Alternative patients were treated with intra-articular injection of either triamcinolone 40mg or PRP. Patients randomized in Steroid group (n=95) were gives intraarticular 40mg Triamcinolone acetate (1ml) along with 2ml of Local anaesthetic Lidocaine 1%, whereas patients randomized in PRP group (n=95) were injected 5ml PRP. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) Scale was used for functional disability and pain before and after the therapy for the targeted knee joint at the baseline 1 week, 5 weeks, 8 weeks and 20 weeks follow-ups. Visual Analogue Scale (VAS) scores were also recorded for pain. Data analysis was done by using SPSS version 20. Results: There wasn’t any serious adverse effect observed during the study and follow-ups. 25 WOMAC functional activity scale showed statistically significant improvement with Intrarticular knee injection of PRP compared to steroids (40.64 ± 1.87 vs. 27.17 ± 6.01) (p = 0.000). WOMAC pain scale results also demonstrated that intrarticular knee injection of PRP was more effective in reducing knee pain than steroids (p = 0.000) at 20 weeks follow-up. Conclusions: On the basis of the results of our study, we concluded that platelet rich plasma is more effective than intra-articular steroids in terms of improvement in functional activity and reduction of pain in patients with Grade I & II knee osteoarthritis. Both PRP and steroid intraarticular injections are safe.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".