The Clinical Efficacy of Cerebrolysin in Ischemic Stroke Patients With Pre-Stroke Mild Cognitive Impairment : a Pilot Study
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Bibliographic record
Abstract
Aim: Assessment of cognitive improvement after cerebrolysin treatment in ischemic stroke patients who suffered from mild cognitive impairment before stroke.Methods: This study had a randomized, placebo-controlled, double-blind design. Patients were randomized within 24 hours post-stroke to either intravenous placebo therapy (n=19) or cerebrolysin 40 ml per day (n=20) for 21 days. Both groups received standard stroke treatment and concomitant treatment for comorbid conditions. Endpoints were MoCA and ARAT scales evaluated three months after discharge. The statistical process was carried out by non-parametric methods with the software Statistica 13.0 (Dell Inc.) based on the LOCF population.Results: The total number of patients included was 39. The average NIHSS score at time of admission was 9.4uf0b10.2 points. Discharge time was 22.3uf0b10.3 days post stroke. At study endpoint patients in the Cerebrolysin group had improved in the MoCA from 23.8uf0b10.2 at baseline to 25.2uf0b10.1 compared to placebo patients who improved from 23.6uf0b10.2 at baseline to 24.1uf0b10.1, a significant group difference (p <0.001). In the ARAT, Cerebrolysin treated patients improved from 29.9uf0b10.2 at baseline to 39.6uf0b10.4 as compared to placebo patients who improved from 34.2uf0b10.7 to 38.6uf0b10.3 points, a significant group difference (p<0.05).Conclusion: Cerebrolysin has a beneficial effect on functional and cognitive performance of mildly cognitive impaired patients who suffered from ischemic stroke. Cerebrolysin was safe and well tolerated.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.016 | 0.011 |
| Science and technology studies | 0.001 | 0.004 |
| Scholarly communication | 0.004 | 0.009 |
| Open science | 0.015 | 0.015 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it