Additional file 2 of Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
Bibliographic record
Abstract
Additional file 2. Fig. S2. 9 month old C57 wild type or 5xFAD (transgenic mice harboring 5 human Alzheimer's mutations involving presenilin and APP (Oakley et al., 2006) were immunolabeled for citrullinated myelin basic protein (citMBP, 1B8 antibody) and Aβ (6E10 antibody), and counter-stained with DAPI. Representative micrographs show no amyloid plaque deposition in the wild type mouse as expected and minimal citMBP in the corpus callosum (CC) indicative of healthy myelin. In contrast, the 5xFAD mouse exhibited heavy plaque deposition typically seen at this advanced age, including in the corpus callosum (*). In this white matter tract notable citMBP signal was observed (arrows) consistent with biochemically damaged myelin. These data are consistent with the notion that in vivo Aβ reaches levels sufficient to induce myelin abormalities, which also appears to occur in the human (Additional file 4).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.024 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.924 | 0.253 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".