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Additional file 1 of Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts

2024· dataset· en· W6958372530 on OpenAlexaff

Bibliographic record

VenueFigshare · 2024
Typedataset
Languageen
FieldComputer Science
TopicMatrix Theory and Algorithms
Canadian institutionsUniversity of ManitobaThrombosis and Atherosclerosis Research InstituteSickKids FoundationUniversity of TorontoUniversity of AlbertaPopulation Health Research InstituteMcMaster UniversityUniversity of British ColumbiaHospital for Sick ChildrenSt. Joseph’s Healthcare Hamilton
Fundersnot available
KeywordsEpigeneticsOffspringGestational ageTable (database)GestationDNA methylationPregnancyGenome-wide association study

Abstract

fetched live from OpenAlex

Additional file1 Table S1. Quality controls for the inclusion/exclusion of samples and methylation probes. Table S2. Characteristics of CHILD and START epigenetic subsample vs. the overall cohort. Table S3. CpGs associated with gestational age in CHILD or START with FDR adjusted p-value < 0.05. Table S4. Measures of type I error inflation for EWAS association p-values in CHILD and START. Table S5. Significantly associated DMR identified in CHILD. Table S6. Significantly associated DMR identified in START. Table S7. Significantly enriched biological pathways for DMRs associated with chronological GA at birth in CHILD and START. Table S8. GWAS genes associated with T2D or GDM mapped to CpGs significantly associated with GA in START or CHILD. Table S9. Enrichment of GWAS genes associated with T2D or GDM using a two-sample binomial test. Table S10. Differences in gestational age, epigenetic gestational age and acceleration between studies or sex. Table S11. Associations between gestational age, epigenetic gestational age, acceleration of gestational age, and maternal and offspring characteristics in CHILD. Table S12. Associations between gestational age, epigenetic gestational age, acceleration of gestational age, and maternal and offspring characteristics in START

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.021
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.571
Threshold uncertainty score0.612

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.021
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.004
Science and technology studies0.0010.000
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.5710.082

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.236
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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