MOESM1 of Relationship between ITPA polymorphisms and hemolytic anemia in HCV-infected patients after ribavirin-based therapy: a meta-analysis
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Bibliographic record
Abstract
Additional file 1: Table S1. Methodological quality of the studies included in the meta-analysis, which was assessed using a modified score based in the Newcastle–Ottawa Scale (Stang A. Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–605). (see Supplemental Box 2). Table S2. Meta-regression analysis for hemoglobin decline (A–C), severe anemia (D) and ribavirin dose reduction or discontinuation (E) according to ITPA polymorphisms. Box 1. Description of rs1127354/rs7270101 haplotype: ITPase deficiency ranged from absent (-) (representing wild-type activity) to mild (+), moderate (++) or severe (+++) (8, 10). Box 2. Methodological criteria used to evaluate the quality of the studies included in the meta-analysis. This score was adapted from Newcastle–Ottawa Scale (Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–605). Figure S1. Publication bias for the rs1127354 studies included in the meta-analysis for hemoglobin decline(A), severe anemia (B) and ribavirin dose reduction or discontinuation (C) according both to Begg’s funnel plots and Egger’s test. Abbreviations: Coef., asymmetry regression coefficient; Std.Err., standard error; t, statistic; P>|t|, significance; and CI, confidence interval. Coefficients correspond to the intercept value in the regression equation, which estimates the asymmetry of the funnel plot. Positive values (Coef.> 0) indicate higher levels of effect size in studies with smaller sample sizes. Figure S2. Publication heterogeneity for studies included in the meta-analysis for hemoglobin decline: rs1127354 (A), rs7270101 (B), rs6051702 (C); severe anemia: haplotype rs1127354CC / rs7270101AA (D); and ribavirin dose reduction or discontinuation: rs1127354 (E); according to Galbraith’s plots. Abbreviations 1/s.e, precision; b/s.e, standardized effect. Figure S3. Sensitivity analysis for studies included in the meta-analysis for hemoglobin decline: rs1127354 (A), rs7270101 (B), rs6051702 (C), haplotype absent (-) vs. mild (+)/moderate (++)/severe (+++) (D), haplotype mild (+) vs. moderate (++)/severe (+++) (E) and moderate (++) vs. severe (+++) (F). Sensitivity analyses were carried out to investigate the influence of any one study on the overall meta-analysis by sequential omission of individual studies. Figure S4. Forest plot of the meta-analysis performed to investigate the association between ITPA rs6051702 polymorphisms and hemoglobin decline, included in the Hwang, et al. Article (32). Abbreviations: CI, confidence intervals; OR, odds ratio. Figure S5. Sensitivity analysis for studies included in the meta-analysis for severe anemia: rs1127354 (A), haplotype absent (-) vs. mild (+)/moderate (++)/severe (+++) (B) and haplotype mild (+) vs. moderate (++)/severe (+++) (C). Sensitivity analyses were carried out to investigate the influence of any one study on the overall meta-analysis by sequential omission of individual studies. Figure S6. Sensitivity analysis for studies included in the meta-analysis for ribavirin dose reduction or discontinuation: rs1127354 (A), haplotype absent (-) vs. mild (+)/moderate (++)/severe (+++) (B), haplotype mild (+) vs. moderate (++)/severe (+++) (C) and moderate (++) vs. severe (+++) (D). Sensitivity analyses were carried out to investigate the influence of any one study on the overall meta-analysis by sequential omission of individual studies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.018 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it