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Record W69635713

Research with Blood Donated to Blood Banking Organizations

2013· article· en· W69635713 on OpenAlex
Nola M. Ries

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueHealth law review · 2013
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsnot available
Fundersnot available
KeywordsBiobankTransfusion medicineBlood transfusionResource (disambiguation)Public relationsMedicineHealth careBusinessPolitical scienceLawBioinformaticsSurgeryBiology
DOInot available

Abstract

fetched live from OpenAlex

Introduction A vast amount of literature examines legal, ethical and social issues involved in collection and use of blood and other biological samples for research purposes. For example, a recent study analyzed nearly 600 papers on consent and biobank (1) Some literatuAre focuses on prospective collection of blood or other biological materials for purpose of creating biobanks as a resource for biomedical Other literature addresses secondary research use of stored samples that were initially collected for clinical purposes. In contrast with wealth of literature addressing these topics, comparatively little has been written about research use of blood that is collected by blood service agencies meet blood supply needs in health care system. Public communication intended motivate people donate blood emphasizes use of blood as a precious resource sustain and save lives. Yet, blood that is collected primarily for medical care may also be stored and used for Some recent literature underscores potential benefits of creating and using repositories of donated blood for research purposes. In an editorial in Transfusion, Allain and Busch argue we feel strongly that research repositories are key advancing field [of transfusion medicine] and should be established and maintained. (2) They also suggest that such repositories can support broader research inquiries beyond those directly related transfusion medicine, that repository samples need be made widely available scientific community and should be linked with other biobanking initiatives. (3) Other researchers discuss opportunities for using blood repositories as a resource for genetic studies. (4) Another scholar cautions, however, that broader research use of blood collected by blood banks raises questions about linking the ethic of with goal of medical research. (5)Indeed, in any efforts expand research uses of blood collected by blood service agencies, it is critically important not undermine trust that donors have in these organizations. And while Allain and Busch advocate for wide research access biorepositories of donated blood, they also acknowledge that to make these resources powerful research tools it is important address ethical and/or informed consent considerations when specimens are collected allow for their future use.... (6) This article explores issues concerning research use of blood donated blood banking organizations. It begins with an overview of practices of these organizations in retaining samples and creating biorepositories. Next, article examines donors' knowledge of and attitudes toward use of donated blood in Available research shows that donors express trust in blood banks make appropriate choices for how donated blood is used, however donors may give little thought research use and focus, instead, on use for medical care purposes. Whatever their level of awareness about research uses, donors maintain a privacy interest in retained samples. The article discusses relevant privacy aspects, then turns a discussion of consent challenges and options. Blood service organizations that wish store, use and share donated samples for research should ensure that consent for research is addressed in a manner than sustains trust relationship between blood bank and donor. The concluding section of article suggests several areas for further research inform policy options for consent research use of donated blood. Blood Service Organizations and Retention and Use of Stored Samples A survey of practices among blood service agencies in more than 15 countries found that most store samples for some period, ranging from several days indefinite storage. A distinction is noted between donation specimens retained primarily for [the blood agency's] operational purposes and collections of donor and/or recipient biospecimens that are made available research community. …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.012
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.792
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0100.012
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.003
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0030.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.502
GPT teacher head0.620
Teacher spread0.118 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it